05 Nov Predicting neonatal RDS with fetal pulmonary artery doppler: a diagnostic performance and ROC curve analysis
Predicting neonatal RDS with fetal pulmonary artery doppler: a diagnostic performance and ROC curve analysis
4 November 2025
Ishan Kumar, Karan Kukreja, Ashok Kumar, Priyanka Aggarwal, Shikha Sachan & Ashish Verma
Methods
This study evaluated Doppler parameters of the fetal main pulmonary artery (MPA) as potential non-invasive predictors of RDS and to assess their relationship with gestational age and postnatal respiratory outcomes.
Pulsed-wave Doppler of the fetal MPA was performed and Doppler indices—pulsatility index (PI), resistance index (RI), peak systolic velocity (PSV), and acceleration time/ejection time ratio (At/Et)—were recorded over three cardiac cycles and averaged. Values were compared after delivery between neonates with and without RDS.
Introduction
In normally developing fetuses, PI and RI decreased while At/Et increased with advancing gestational age. In contrast, fetuses who developed RDS showed persistently low At/Et and elevated PI and RI values. Cutoff values of At/Et < 0.24, RI > 0.8, and PI > 2.16 were effective in predicting RDS.
The severity of RDS was associated with greater deviations from these values. Altered Doppler indices were found to be independent predictors of RDS in preterm neonates.
Conclusion
Fetal MPA Doppler parameters serve as reliable, non-invasive predictors of RDS and the severity of RDS in preterm neonates.
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