Estimate the severity of acute ischemic stroke by optic nerve sheath ultrasound

Estimate the severity of acute ischemic stroke by optic nerve sheath ultrasound

8 December 2025

Sara Esmaeili, Farzan Vahedifard, Fatemeh Ebrahimi, Hossein Nazarian, Arian Shahidi, Zahra Mirzaasgari & Mohammadreza Maghsoudi

Background

To investigate the diagnostic value of three-dimensional superb micro-vascular imaging (3D-SMI) combined with quantitative analysis of Area and VI in differentiating benign and malignant renal tumors.

Methods

Timely diagnosis of acute ischemic stroke can aid optimal treatment. Optic nerve sheath diameter (ONSD) can determine increased intracranial pressure (ICP) in such cases. The purpose of this study is to determine the value of ONSD in estimating the severity of acute ischemic stroke.

Results

A strong correlation was found between increased right and left ONSDs and severity of ischemic stroke determined by the initial NIHSS score.

Based on ROC curve (receiver operating characteristic curve) analysis, both cut points of 5.65 mm for right ONSD (with 100% sensitivity of and 86% specificity) and 5.75 mm for left ONSD (with a 100% Sensitivity and 88% specificity) were able to predict severe stroke.

The value of the right ONSD (Area Under the Curve = 0.959) and the left ONSD (Area Under the Curve = 0.942) indicated a strong predictive value.

Conclusion

Ultrasound as a feasible and non-invasive modality might play a role in determining the severity of an acute ischemic stroke, and could be considered a promising first-line decision making tool.

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